Clinical and Translational Science Award
Cincinnati CTSA proposal abstract, January 2015
The vision of the Center for Clinical and Translational Science and Training (CCTST) at the University of Cincinnati is to be the Greater Cincinnati portal of entry for support of clinical and translational research with a goal to enfranchise stakeholders from a broad base to integrate research into healthcare delivery, improve community wellness, foster effective, efficient multisite trials, and train the clinical and translational research workforce of the future. We will realize this vision through three aims: (1) Empower stakeholders in the process of integrating research with healthcare practice and community wellness, (2) Create the workforce of the future, and (3) Optimize efficiency and effectiveness of clinical research. Building on the successes of the last 6 years, we propose innovative changes to existing programs and creation of new programs designed to provide support for high quality cutting-edge research done by teams of scientists. Building on our existing programs, we propose to (1) provide innovative programs in career development for a wide range of learners, (2) develop new pilot programs to support creation of solutions for obstacles to research, (3) expand our community engagement program to extend beyond Greater Cincinnati to stakeholders across the U.S., (4) provide more comprehensive support by biomedical informatics for the services provided by the CCTST, (5) expand support for patient-oriented research, and (6) help overcome regulatory and ethical challenges that impede clinical research in local and multisite studies. We propose innovative efforts directed toward fostering learning health networks and creating a Research Commons to provide more comprehensive support to investigators. We will focus on (1) teaching and implementing team science principles and encouraging collaboration across a variety of disciplines and stakeholders, (2) consolidation of clinical trials support across the academic health center by creating Cinci-HERO to help multicenter trials for which the CCTST affiliates are the leads (including serving as the IRB of record) or site participants and recruitment of populations across the lifespan including underrepresented minorities, those with environmental exposures and health disparities, and (3) acute care research and lifespan data integration that takes advantage of institutional strengths.
Cincinnati CTSA proposal abstract, June 2008
The vision of the University of Cincinnati Academic Health Center (AHC) Institutional CTSA is to create an environment to facilitate translating discoveries to clinical application. Our new academic home for clinical and translational research, the Center for Clinical and Translational Science and Training (CCTST), is beginning to transform the research environment within the AHC and our affiliated partners in other areas of the University, the community, and industry. The CCTST will coordinate and plan the overall direction of AHC research infrastructure and training opportunities; serve investigators’ needs from project concept to completion; optimize skills and foster career development of both new and experienced investigators; and ensure that community input informs research processes, and that AHC discoveries are translated to the community.
The CCTST will coordinate and leverage our existing strengths and develop new initiatives. Through Research Central, researchers will have easy access to centralized study design, biostatistical, bioinformatics, regulatory, and community engagement support. The new Pilot & Collaborative Studies core will expand the highly successful pilot funding program at Cincinnati Children’s Hospital Medical Center (CCHMC) to the entire AHC. Biomedical informatics will be coordinated across the AHC. A new K12 program and greatly expanded educational offerings, including a new Certificate in Clinical and Translational Research, will be developed, building on the success of our Dean’s Scholars in Clinical Research and K30-funded MS in Clinical and Translational Research programs. Through our community engagement program, we will further bi-directional research linkages with the local community, breaking down bureaucratic barriers by creating IRBs that can coordinate community-based research. Expanding services such as nursing/coordinator support and sample processing provided by the existing General Clinical Research Center (GCRC) at CCHMC and the Cincinnati Veterans Affairs Medical Center will promote patient-oriented research for populations outside the GCRC in the community. New translational technologies, including proteomics, drug discovery, imaging, nanomedicine, gene transfer and stem cell biology and translational and molecular disease modeling, will be made more accessible to researchers. Throughout, we will utilize a quality improvement model to evaluate our progress. These efforts will facilitate transforming clinical and translational research at the AHC, leading to improved health outcomes in the community.
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