The KL2 Research Scholars Mentored Career Development Award is offered to highly qualified junior faculty pursuing careers in clinical and translational research. The KL2 program provides mentorship, career development opportunities, and financial support for salary and research-related expenses for up to two consecutive years. During the award period, Scholars are expected to pursue their own K23 (or similar individual career development awards) or R01 grants. Also involved in the Program are CT2 Scholars, which have the same goals and requirements as the KL2 but have a different funding structure.
All 8 of the current KL2 and CT2 Scholars are doing exceptional work across the Academic Health Center. Below are a few recent Scholar highlights:
Aristide Merola, MD, PhD, Neurology and Rehabilitation Medicine, College of Medicine, University of Cincinnati, has been an appointed KL2 Scholar since 2017. Dr. Merola was recently involved in conducting a systematic review and meta-analysis to determine if the results of subthalamic deep brain stimulation (DBS) surgery vary among different forms of Parkinson’s disease. DBS is a therapy used to improve motor functions in patients with Parkinson’s disease. The project, titled, “Association of Subthalamic Deep Brain Stimulation With Motor, Functional, and Pharmacologic Outcomes in Patients With Monogenic Parkinson Disease”, involved 518 patients from 17 published studies. The analysis found that the DBS treatment yielded similar results in motor function changes, but the dopaminergic doses, activities of daily living, motor complications, and cognitive function outcomes varied in patients with different gene mutations (LRRK2, GBA, or PRKN). The analysis was published in JAMA Network in February 2019; click here for more details.
Dr. Merola was also invited to present at the National German Meeting of Parkinson’s Disease in March 2019, where he spoke on, “Efficient Directional DBS Programming: Translating Directional DBS best programming practices in Clinical Studies to the Clinic with the InformityTM interface”.
The Association for Clinical and Translational Science (ACTS) hosts a national meeting each year in Washington D.C. with the mission of bringing together all of the disciplines involved in clinical and translational research, for the shared benefits of networking and education. Four CCTST KL2/CT2 Scholars presented at the 2019 meeting in March:
- Moises Huaman, MD, MSc, poster presentation: Mycobacterium bovis Bacille-Calmette-Guérin infection aggravates atherosclerosis
- Stephanie Merhar, MD, MS, poster presentation: Reduced structural and functional connectivity in infants with prenatal opioid exposure
- Timothy Phoenix, PhD, poster presentation: Brainstem In Utero Electroporation Models of Pediatric Diffuse Intrinsic Pontine Glioma
- Elizabeth Kramer, MD, PhD, platform and poster presentation: TGFbeta, Early Cytokine Dysregulation, and Airway Smooth Muscle Dysfunction in Cystic Fibrosis
Learn More at Grand Rounds:
Interested in learning more about the Scholars and their research? Five Scholars will be presenting at the CCTST Grand Rounds on May 17, 2019. Click here for additional details and registration.
Post date: April 25, 2019