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Pilot Translational and Clinical Studies

The Pilot Translational and Clinical Studies (PTC) Core is directed by Bruce Trapnell, MD, MS, professor of pediatrics and assistant director, CCHMC Adult Cystic Fibrosis Center and co-directed by Frank McCormack, MD, professor and director, division of pulmonary, critical care and sleep medicine, UC College of Medicine.

The new Pilot Translational Research and Innovative Core Grant Program, which has replaced the "T1" Pilot Grant Program, supports projects by established principal investigators or by new/early stage investigators mentored by established investigators, and also promotes the establishment of new, innovative cores with a clear translational focus, to build a local or networked infrastructure.  Please see details below.

Pilot Translational Research and Innovative Core Grant Program

OVERVIEW
An integral part of the CCTST mission is stimulating development of pre-clinical and human clinical trials that seek to improve medical care.  The CCTST Pilot Translational Research and Innovative Core Grant Program will support projects by established principal investigators, or by new/early stage investigators mentored by established investigators, focused on applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans.  The Program also promotes the establishment of new, innovative cores with a clear translational focus, to build a local or networked infrastructure.

KEY DATES

  • Letter of Intent (LOI) due: October 22, 2015 before midnight
  • Invitation to submit a grant application: December 1, 2015
  • Grant applications due from invited applicants: January 10, 2016 before midnight
  • Notification of Grant Award (NOGA): February, 2016
  • Start date (funds first available): July 1, 2016

GRANT TYPES
Translational Research Grant (TRG):  Supports established investigators seeking to conduct a novel translational research project. The funding period is limited to one year. The maximum allowable budget (direct costs) is $60,000.  

Mentored Translational Research Grant (MTRG):  Supports new and early stage investigators seeking to conduct a novel translational research project. Important requirements of this grant mechanism are the inclusion of a clear letter of support from an established mentor and a detailed description of the Mentee’s training plan and interactions with the mentor. The funding period is limited to one year. The maximum allowable budget (direct costs) is $60,000.

Innovative Core Grant (ICG): Helps build adequate local infrastructure to support clinical and translational research by providing funds to establish new shared Core facilities with a clear translational focus. The maximum allowable budget (direct costs) is $50,000 per year.

A second year of funding for any grant type is possible.  Grantees are required to submit a Letter of Intent and a one page “Progress to Date” report justifying the need for continued support. 

RESEARCH PRIORITIES

Priority will be given to projects which:

  • are farthest along in preclinical or early clinical development
  • seek to increase communication and collaboration between clinicians or clinical researchers and basic scientists
  • seek to increase collaboration between investigators in different institutions within the Academic Health Center (AHC).  The program is particularly interested in promoting collaborations between investigators at UCMC and CCHMC and between investigators at either UCMC or CCHMC and those at UC’s west campus.
  • have clearly described plans to utilize the results as preliminary data in an application soliciting extramural funding
  • are focused on new research or technological development with a high likelihood of leading to patent or licensing opportunities

Consideration will be given to proposals that promote interactions between AHC investigators and members of the community.

ELIGIBILITY

Investigators with a faculty appointment of at least 80% FTE,  including individuals from the AHC (UCMC, CCHMC, VAMC) or the UC west campus, including basic scientists, physicians, nurses, and other health care faculty with advanced degrees (MD, PhD, MD-PhD, or equivalent) are potentially eligible. The PI or Co-I who is applying must either currently hold a faculty appointment at UC or CCHMC or expect to hold one at the time of the award at the level of Instructor, Assistant Professor, Research Assistant Professor, Associate Professor, or Professor. Collaborative teams of investigators spanning disciplines and programs made up of basic and clinical faculty are strongly encouraged to apply. See the program announcement for complete details on eligibility.  Applicants must be CCTST members.  Join here free of charge.

SUBMISSION

LOIs and invited full applications must be submitted through the CCTST Competition and Awards Program Site (CCAPS).  Log in using your UC (“6+2”) or CCHMC username and password.

DETAILS

For complete details, view the program announcement (RFA).  If you have questions, email Beth Hezlep or call 513-803-7039.


Information on the former T1 program is available here:


Just-In-Time Core Grant Program

Next application deadline is February 1, 2016

The mission of the Just-In-Time (JIT) grant mechanism is to enable investigators to use UC or CCHMC Core facilities to obtain critical data for submission of a competitive extramural proposal, patent application or commercialization agreement.  Offered twice this fiscal year, this small grants program is designed to support clinical and translational science investigators who require the services of an institutional core to develop key preliminary data for federal (K23, R01, DOD, VA, etc.), foundation or professional association grant funding.  Investigators may apply for up to $7,500 annually for core services that would directly facilitate the submission of a new or revised application for extramural funding. The Just-In-Time funding must be spent within the fiscal year awarded (by June 30, 2016).

Please note that applications must be submitted through the CCTST Competition and Awards Program Site (CCAPS):  https://ccaps.research.cchmc.org/welcome.  Log in using your UC (“6+2”) or CCHMC username and password.

Just-In-Time Program participating core facilities:

  1. Animal Behavioral Core (CCHMC)
  2. Cardiovascular Imaging Core (CCHMC)
  3. Cell Manipulations Laboratory (CCHMC)
  4. Center for Autoimmune Genomics and Etiology (CAGE, CCHMC)
  5. Center for Imaging Research (UC)
  6. Confocal Imaging Core (CCHMC)
  7. Diagnostic Immunology Lab (CCHMC)
  8. DNA Sequencing and Genotyping Core- Computational Medicine Center (CCHMC)
  9. Gene Expression Core (CCHMC)
  10. Genomics, Epigenomics and Sequencing Core (UC)
  11. Heart Phenotype Lab (UC)
  12. Human Genetics Core (CCHMC)
  13. Imaging Research Center (CCHMC)
  14. Laboratory Animal Medical Services (LAMS, UC)
  15. Live Microscopy Core (UC)
  16. Mass Spectrometry Facility (Clinical and Biomedical) (CCHMC)
  17. NMR-based Metabolomics Core (CCHMC)
  18. Pathology Research Core (CCHMC)
  19. Pharmacometrics Core (UC/CCHMC)
  20. Pluripotent Stem Cell Facility (CCHMC)
  21. Protein Informatics Core (UC/CCHMC)
  22. Proteomics Laboratory (UC)
  23. Pyrosequencing Lab for Genomic and Epigenomic Research (CCHMC)
  24. Research Flow Cytometry Core (CCHMC)
  25. Structural Biology and Protein Expression/Purification Facility (UC)
  26. Transgenic Animal and Genome Editing Core Facility (CCHMC)
  27. Translational Trials Development and Support Laboratory (CCHMC)
  28. Vector Production Facility (CCHMC)
  29. Viral Vector Core (CCHMC)
  30. Vontz Core Imaging Laboratory (UC)

 


Processes and Methods Pilot Grant Program

Next deadline is March 1, 2016

This pilot grant mechanism enables investigators at all levels to explore ways to improve the efficiency and effectiveness of the processes and methods used in clinical and translational research. 

Each of the 3-5 funding rounds per year will have a specific focus.  For the March 1, 2016 deadline, proposals are requested that describe innovative processes or methods for recruiting underrepresented minorities in clinical research, particularly applications that align with the following areas:

  1. Identification of barriers and strategies for research participation.
  2. Involving community leaders and fostering multisector collaborations.
  3. Innovative partnerships and technology.

Applications will be accepted from faculty or staff from all UC campuses, the Academic Health Center (including CCHMC, UC, VAMC, UCMC), or any of the regional colleges/universities including Xavier, Mount Saint Joseph, NKU, Thomas More, and Miami. Investigators may include, but are not limited to, clinical research professionals and data management specialists.  This program is also open to members of the Greater Cincinnati community and patient advocacy groups at a local, regional or national level.  Advanced degrees (MD, PhD, MD-PhD or equivalent) are not required for eligibility.  Collaborative groups of investigators spanning disciplines and programs are strongly encouraged. Submissions from underrepresented and minority investigators are also encouraged.  Applicants must be CCTST members.  Join free of charge.

Funding requests of up to $10,000 are acceptable.  Special requests of up to $20,000 must be approved prior to submission.  Each submission deadline (3-5 per fiscal year) will have a specific focus, such as streamlining informed consent or improving research participants' understanding of complex information.  See the RFA linked below for details. 

The one page application and required documents must be submitted as a single pdf file through the CCTST Competition and Awards Program (CCAPS) site by the deadline date. See the request for applications (RFA) below for complete details.

Questions?  Email Beth Hezlep or call (513) 803-7039.


Retreats/Workshops/Symposia Matching Funds Program

Support is available for multidisciplinary retreats/workshops/symposia (on- or off-campus) that will further the mission of the CCTST. Ideally, these events will provide a rich forum for basic, translational, and clinical scientists to interact and develop new initiatives. Up to $3,000 per event is available from the CCTST, contingent upon the availability of matching funds derived from other sources (typically clinical or research division resources or grants). UC faculty with 80% or greater FTE, including those based at Cincinnati Children’s Hospital Medical Center and Cincinnati Veterans Affairs Medical Center, are generally eligible to apply. Funds are limited and awards are made on a continuing basis, so application early in the fiscal year is encouraged. An application must be submitted at least 60 days in advance of the proposed event.  For more information, email Beth Hezlep or call (513) 803-7039.  See link below for complete details.


For more information on programs of the PCS Core, email Beth Hezlep or call (513) 803-7039.

Programs