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Pilot Translational and Clinical Studies

The Pilot Translational and Clinical Studies (PTC) Core is directed by Bruce Trapnell, MD, MS, professor of pediatrics and assistant director, CCHMC Adult Cystic Fibrosis Center and co-directed by Frank McCormack, MD, professor and director, division of pulmonary, critical care and sleep medicine, UC College of Medicine.

The new Pilot Translational Research and Innovative Core Grant Program (P1), which has replaced the “T1” Pilot Grant Program, supports projects by established principal investigators or by new/early stage investigators mentored by established investigators, and also promotes the establishment of new, innovative cores with a clear translational focus, to build a local or networked infrastructure. Please see details below.

Pilot Translational Research and Innovative Core Grant Program (P1)

Overview

An integral part of the CCTST mission is stimulating development of pre-clinical and human clinical trials that seek to improve medical care. The CCTST Pilot Translational Research and Innovative Core Grant Program will support projects by established principal investigators, or by new/early stage investigators mentored by established investigators, focused on applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans. The Program also promotes the establishment of new, innovative cores with a clear translational focus, to build a local or networked infrastructure.

Key Dates

  • Letter of Intent (LOI) due: September 30, 2016 before midnight
  • Invitation to submit a grant application: October 31, 2016
  • Grant applications due from invited applicants: December 16, 2016 before midnight
  • Notification of Grant Award (NOGA): March, 2017
  • Start date (funds first available): July 1, 2017

Grant Types

Translational Research Grant (TRG): Supports established investigators seeking to conduct a novel translational research project. The funding period is limited to one year. The maximum allowable budget (direct costs) is $60,000.

Mentored Translational Research Grant (MTRG): Supports new and early stage investigators seeking to conduct a novel translational research project. Important requirements of this grant mechanism are the inclusion of a clear letter of support from an established mentor and a detailed description of the Mentee’s training plan and interactions with the mentor. The funding period is limited to one year. The maximum allowable budget (direct costs) is $60,000.

Innovative Core Grant (ICG): Helps build adequate local infrastructure to support clinical and translational research by providing funds to establish new shared Core facilities with a clear translational focus. The maximum allowable budget (direct costs) is $50,000 per year.

A second year of funding for any grant type is possible. Grantees are required to submit a Letter of Intent and a one page “Progress to Date” report justifying the need for continued support.

Research Priorities

Priority will be given to projects which:

  • are farthest along in preclinical or early clinical development
  • seek to increase communication and collaboration between clinicians or clinical researchers and basic scientists
  • seek to increase collaboration between investigators in different institutions within the Academic Health Center (AHC). The program is particularly interested in promoting collaborations between investigators at UCMC and CCHMC and between investigators at either UCMC or CCHMC and those at UC’s west campus.
  • have clearly described plans to utilize the results as preliminary data in an application soliciting extramural funding
  • are focused on new research or technological development with a high likelihood of leading to patent or licensing opportunities

Consideration will be given to proposals that promote interactions between AHC investigators and members of the community.

Eligibility

Investigators with a faculty appointment of at least 80% FTE, including individuals from the AHC (UCMC, CCHMC, VAMC) or the UC west campus, including basic scientists, physicians, nurses, and other health care faculty with advanced degrees (MD, PhD, MD-PhD, or equivalent) are potentially eligible. The PI or Co-I who is applying must either currently hold a faculty appointment at UC or CCHMC or expect to hold one at the time of the award at the level of Instructor, Assistant Professor, Research Assistant Professor, Associate Professor, or Professor. Collaborative teams of investigators spanning disciplines and programs made up of basic and clinical faculty are strongly encouraged to apply. See the program announcement for complete details on eligibility. Applicants must be CCTST members. Join here free of charge.

Submission

LOIs and invited full applications must be submitted through the CCTST Competition and Awards Program Site (CCAPS). Log in using your UC (“6+2”) or CCHMC username and password.

Details

For complete details, view the program announcement (RFA). If you have questions, email Jonathan Hoehn or call 513-803-8575.


Information on the former T1 program

More Grant Programs

Just-In-Time Core Grant Program

The mission of the Just-In-Time (JIT) grant mechanism is to enable investigators to use UC or CCHMC Core facilities to obtain critical data for submission of a competitive extramural proposal, patent application or commercialization agreement.
more details about Just-In-Time Core Grant Program…

Processes and Methods Pilot Grant Program

This pilot grant mechanism enables investigators at all levels to explore ways to improve the efficiency and effectiveness of the processes and methods used in clinical and translational research.
more details about Processes and Methods Pilot Grant Program…

Retreats/Workshops/Symposia Matching Funds Program

Support is available for multidisciplinary retreats/workshops/symposia (on- or off-campus) that will further the mission of the CCTST.
more details about Retreats/Workshops/Symposia Matching Funds Program…


For more information on programs of the PCS Core, email Jonathan Hoehn or call (513) 803-8575.

Programs